abstract |
Acyl-CoA binding protein [“ACBP”] binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. This protein is expected to play an important role in altering lipid production in oleaginous microbial organisms. Knock-out of the protein in the oleaginous yeast, Yarrowia lipolytica , results in a decrease in the total lipid content, while overexpression results in an increase in the total lipid content of the recombinant Yarrowia cells. |