| abstract |
The present invention provides an excellent antihypertensive medicament. The medicament of the present invention comprises a compound having the general formula (I) and the like: n n n n n n n n n n n n [wherein R 1 : H, substitutable alkyl, substitutable alkenyl, substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; R 2 : H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R 3 , R 4 ; H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R 5 , R 6 : H, substitutable alkyl, substitutable cycloalkyl, substitutable alkoxy or the like; R 7 , R 8 : H, substitutable alkyl, substitutable cycloalkyl or the like; X: the formula (II) or the like; A: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; Y: a single bond, substitutable alkylene, substitutable alkenylene, —(CH 2 ) a —X 1 —(CH 2 ) b —(X 1 : the formula —NH—, —O— or the like; a, b: 0-5) or the like; B: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like]. |