| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_322a1e11efdf796e01e150ac44c08d37 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4965 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4965
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
| filingDate |
2009-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77fd25227b4ed16e2554613457f06801 |
| publicationDate |
2009-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009286799-A1 |
| titleOfInvention |
Methods for the treatment of brain edema |
| abstract |
The present invention is based on the discoveries that PAN-811 (1) reduces infarct volume, suppresses brain edema and decreases mortality associated with ischemia; (2) blocks veratridine-induced swelling and neuronal cell death; (3) chelates free calcium and inhibits MMP-9 activity; and (4) blocks calcium-induced neuronal cell death and suppresses glutamate-induced calcium influx into neuronal cells. More particularly, the present invention relates to methods for treating, ameliorating or preventing vasogenic and/or cytotoxic brain edema, by administering to a subject in need thereof certain thiosemicarbazone compounds or pharmaceutically acceptable salts thereof. An example of such a thiosemicarbazone is 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014031366-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013169361-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019147839-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548890-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014152864-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014153505-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11045466-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107714696-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307418-B2 |
| priorityDate |
2008-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |