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filingDate 2009-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2009-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2009274702-A1
titleOfInvention Method of treatment and Agents useful for same
abstract The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
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