| abstract |
The present invention aims to provide a novel pyrazole derivative and a pharmaceutical agent containing the same. The present invention provides a compound represented by the formula (I′) n n n n n n n n n n whereinn R 1 ′ is (1) a hydrogen atom, (2) a group via a carbon atom, (3) a group via a nitrogen atom, (4) a group via an oxygen atom or (5) a group via a sulfur atom; R 2 ′ is an aromatic ring group optionally having substituent(s); R 3 ′ is (1) a hydrogen atom, (2) a group via a carbon atom, (3) a group via a nitrogen atom, (4) a group via an oxygen atom or (5) a group via a sulfur atom; R 4 ′ is a cyanophenyl group optionally having substituent(s); X′ is (1) —Y′—CR 5 ′R 6 ′-Z′- wherein R 5 ′ and R 6 ′ are the same or different and each is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom or a group via a sulfur atom, or —CR 5 ′R 6 ′— is —C(alkylidene)-; Y′ is a bond, —COCO—, —CONH—, —COCONH— or —O—; and Z′ is a bond, —CH 2 —, —CONH—, —O—, —OCH 2 —, —S—, —SO—, —SO 2 —, —CON(C 6 H 5 )— or nn n n n n n n n n n (2) —CO(CONH) n — wherein n is 0 or 1, n (3) —NHCO—, n (4) —CONH—, n (5) —O—, n (6) —CH═CH— or n (7) —O(C 1-3 alkylene)O—; (excluding the compounds indicated to be excluded from the specification), or a salt thereof. |