| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9673d23b329bf20b3f977b7531a7508f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71979d67a090d93ac0e40d365c9b6097
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac0304826cefc4b52af1129782ebd06e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_005fdd754089e88bff1bfaf50c37845d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate |
2009-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73fe30c64724006f4ce7996fcff9d281
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91c352b6f55d2b1ab441047df39984a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6078621ad0e7d2e21ff5926b052689c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2475bab933aaacde617ee8ab43aed76b |
| publicationDate |
2009-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009269386-A1 |
| titleOfInvention |
Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use |
| abstract |
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11478574-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10314940-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016033322-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739291-B2 |
| priorityDate |
2006-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |