http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009264628-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b5c7ac62800ffaf3eef10a390a9490b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7aa001f3235c07b0298867908d45e21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06G7-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate | 2006-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5eb676a85039f4d1810b63b9bc3d219b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68610f483ebd4cb3a1c1bab4c26cde0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9693c306746b76e170770549584550f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce1d980ba8e3e1a1f288544df06f853f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_506b51786e1e041c47ae1ef7143cc02e |
| publicationDate | 2009-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009264628-A1 |
| titleOfInvention | Crystal structure of human urokinase plasminogen activator amino teminal fragment bound to its receptor |
| abstract | Urokinase-type plasminogen activator (uPA) binds its cellular receptor (uPAR) with high affinity, thus localizing the generation of plasmin from plasminogen on the surface of a variety of cells. Disclosed herein is the structure of suPAR (uPAR 1-277 ) complexed with the amino terminal fragment (ATF) of uPA (uPA 1-143 ) at a resolution of 1.9 ú by X-ray crystallography. Three consecutive domains of uPAR (D1, D2 and D3) form the shape of a thick-walled teacup with a cone shape cavity in the middle, which has a wide opening (25 ú) and large depth (14 ú). uPA 1-143 inserts into the cavity of uPAR and forms a large interface. The structure provides the basis for high affinity binding between uPA and uPAR and suggests the D1 and D2 domain of uPAR and the GFD domain of uPA (uPA 7-43 ) are primarily responsible for uPA-uPAR binding. This structure presents the first high resolution view of uPA-uPAR interaction, and provides, among other things, a new platform for designing uPA-uPAR inhibitors/antagonists. |
| priorityDate | 2005-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.