| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32a6a661b3503d8edf3968a23c29da45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea2c0d0dcb67d4a3c3831d91df0d6eb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55683405446c06359bb8a6df4ba174a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_687712c1096adb834e79c2844056a29f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7069 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L15-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-568
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-006 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-216 |
| filingDate |
2007-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11cb70f5c9e753cb2514a786680a5822
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24b4dbe1bfd9c5b56df1af40143d90f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41e83a6ffd925b6bda1df934b430d095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9a4070bfda4d94412aed5bf6e829869 |
| publicationDate |
2009-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009264385-A1 |
| titleOfInvention |
Stabilized compositions containing alkaline labile drugs |
| abstract |
A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion. Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015209980-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9440377-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011139486-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023150345-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009214685-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020061071-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9278140-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014065870-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013150542-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013150542-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012094163-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9107815-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011139486-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9981022-B2 |
| priorityDate |
2006-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |