| abstract |
The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include the following: n n n n n n n n n n wherein R 1 and R 2 are each H or C 1-6 alkyl. X is C 1-6 alkylene. R 3 is H, —OR 4 , —OC(O)R 4 , —OC(O)NR 4 R 5 , —OC(O)OR 4 , —OP(O)(OR 4 ) 2 or —OC(O)(CH 2 ) 2 C(O)OH. R 4 and R 5 are each independently H or C 1-20 alkyl. The compounds also include salts, hydrates and isomers of the compounds. |