| abstract |
Glycolipid derivatives having the formula (I): n n n n n n n n n n wherein R 1 indicates an aldopyranose residue, R 2 indicates a hydrogen atom or hydroxyl group, A indicates —CH 2 —, —CH(OH)—CH 2 — or —CH═CHCH 2 —, Z indicates —O— or —CH 2 —, when Z is —O— and x is an integer of 4 to 16, y indicates an integer of 26 to 35, when Z is —O— and x indicates an integer of 17 to 25, y indicates an integer of 0 to 35, when Z is —CH 2 — and x indicates an integer of 4 to 15, y indicates an integer of 26 to 35, and when Z is —CH 2 — and x indicates an integer of 16 to 25, y indicates an integer of 0 to 35 and a drug containing the glycolipid derivative for treatment of autoimmune arthritis and other autoimmune disease, bronchial asthma and other allergic diseases or diseases in which NKT cells or stimulation of NKT cells is known to be participating in the deterioration of conditions. |