| abstract |
The invention provides chroman compounds having formula 1 n n n n n n n n n n wherein R 1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R 1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R 4 is H, Hal, CF 3 , OH or (1C-2C)alkyloxy; R 2 , R 3 , and R 5 are independently H, Hal, CF 3 , (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments. |