| abstract |
The present invention relates to novel compounds of formula (I) or a salt thereof: n n n n n n n n n n wherein:n np is 0, 1, 2, 3, 4 or 5;n nR 1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl and SF 5 ;n nn is 3 or 4;n nR 2 is hydrogen or C 1-4 alkyl;n nn is 2 or 3;n nX is —CH 2 —, —O— or —S—;n nZ may be —CH— or N;n nA is a group P or P1,n nwherein P isn n n n n n n n n n n and P1 is n n n n n n n n n n ; andn nY is hydrogen, —OH, C 1-4 alkyl, haloC 1-4 alkyl, phenyl or a heteroaromatic group, wherein the phenyl and the heteroaromatic group are optionally substituted by one or two substituents selected from a group consisting of C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy and haloC 1-4 alkoxy;n nprocesses for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat substance related disorders, as antipsychotic agents premature ejaculation or cognition impairment. |