http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009191125-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01a96e8bbea00eeaa0b50c2a0c000dba |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 |
| filingDate | 2008-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5abaefd50472490919da210e6d0140ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04a9ef146c6f1e1d64a86c9169269a29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5779d148915164a7085e557c438df434 |
| publicationDate | 2009-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009191125-A1 |
| titleOfInvention | Diagnostic and Therapeutic Alkyl Piperidine/Piperazine Compounds and Process |
| abstract | Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: n n n n n n n n n n wherein:n nn is an integer of 1 to 6; X, Y, Z 1 and Z 2 can be the same or different and are hydrogen, halo, haloalkyl, alkyl, aryl, (C 1 -C 6 ) alkoxy, N-alkyl,(C 2 -C 6 ) acyloxy, N-alkylene, —SH, —SR, wherein R is from the same group as R 1 and R 2 and can be the same or different than R 1 and R 2 , amino, nitro, cyano, hydroxy, C(═O)OR 6 , —C(═O)NR 5 R 4 , NR 3 R 2 , or S(═O) k R 1 wherein k is 1 or 2, and R 1 to R 6 are independently hydrogen or (C 1 -C 6 ) alkyl;n R 1 , and R 2 can be the same or different and are hydrogen, (C 1 -C 6 ) alkyl, hydroxyalkyl or mercaptoalkyl, —C(═O)OR 1 , cyano, (C 1 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, or 1,2,4-oxadiazol-5-yl optionally substituted at the 3-position by Z 4 wherein any (C 1 -C 6 ) alky, (C 1 -C 6 ) alkanoyl, (C 2 -C 6 ) alkenyl or (C 2 -C 6 ) alkynyl can optionally be substituted by 1, 2 or 3 Z; R 7 can be hydrogen, O or phenyl R 8 can be hydrogen, phenyl, halophenyl, nitrophenyl, pyridyl, piperonyl or sulfoxonitrophenyl Z 4 is (C 1 -C 6 ) alkyl or phenyl, optionally substituted by 1, 2 or 3 Z 1 W is O or S T is amino or C 1 -C 6 aminoalkyl A is N or C T is C 1 -C 6 alklyl or sulfonyl and V is alkyl (C 0 -C 6 ), alkenyl, alkynyl, haloaryl, alkyl phenol, alkyl halophenyl, and R 1 or R 2 as indicated above and φ is phenyl, naphthyl, thienyl or pyridinyl. |
| priorityDate | 2004-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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