abstract |
A compound of the formula (I), and pharmaceutically acceptable salts thereof, wherein: R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of H, C 1-7 alkoxy, amino, halo or hydroxy; Y is —CR C1 R C2 —(CH 2 ) m —, where m is 0 or 1, R c1 is selected from CH 3 and CF 3 , and R c2 is selected from H and CH 3 , or R C1 and R C2 together with the carbon atom to which they are attached form the 1,1-cyclopropylene group (a), R N1 and R N2 are independently selected from H and R, where R is optionally substituted C 1-10 alkyl, C 3-20 heterocyclyl and C 5-20 aryl; or R N1 and R N2 , together with the nitrogen atom to which they are attached form an optionally substituted 5-7 membered, nitrogen containing, heterocyclic ring; Het is selected from: (i), where Y 1 and Y 3 are independently selected from CH and N, Y 2 is selected from CX and N and X is H, Cl or F; and (ii), where Q is O or S. |