| abstract |
A tetrapyrollic photosensitizer compound having at least one pendant —CH 2 CH 2 CON(CH 2 CON(CH 2 COOH) 2 ) 2 or —N(CH 2 COOH) 2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: n n n n n n n n n n or a pharmaceutically acceptable derivative thereof, wherein R 1 -R 8 and R 10 are various substituents and R 9 is substituted or unsubstituted —CH 2 CH 2 CON(CH 2 CON(CH 2 COOH) 2 ) 2 ; or —N(CH 2 COOH) 2 . The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound. |