| abstract |
Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1. n A compound represented by the formula: n n n n n n n n n n a pharmaceutically acceptable salt or solvate thereof,n nwhereinn nR 1 is a group of the formula: —C(═O)NR 4 R 5 ,n n(wherein R 4 and R 5 are each independently, hydrogen, optionally substituted alkyl or the like) orn na group of the formula: —NR 6 C(═O)R 7 ,n n(wherein R 6 and R 7 are each independently, hydrogen, optionally substituted alkyl or the like),n nX and Y are each independently —O— or the like,n nZ is a bond or the like,n nR 2 is optionally substituted alkyl, optionally substituted alkenyl or the like,n nR 3 is optionally substituted alkyl, optionally substituted alkenyl or the like. |