| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6421 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06G7-48 |
| filingDate |
2007-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb7ac2c95f9d8f1c9c0ac905a0d790df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbbd11a7b571e85ffab50276114fa242
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5efb8232d8ca56347b945354573f385e |
| publicationDate |
2009-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009125289-A1 |
| titleOfInvention |
Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
| abstract |
An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three-dimensional x-ray crystal structure has been solved to 3.2 Å resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11008403-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8772457-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10882920-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879094-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11746160-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9453079-B2 |
| priorityDate |
2000-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |