| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_799b6c8cb40ea97102dceda7bfe7b5c7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-54 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5161
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-337 |
| filingDate |
2007-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dde77966c91c8efc044ada65832c7b72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59c5e9f41524fb509bc78b6cdf93e817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fe8f1273138ae1b90ec7eda1372f734
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8565fd8b6be88f19d5df6c7efd31c4ee |
| publicationDate |
2009-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009124817-A1 |
| titleOfInvention |
Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles |
| abstract |
The present invention relates to a method of preparing amorphous atorvastatin calcium nanoparticles using a supercritical fluid process. Specifically, the method comprising the steps of: a) dissolving atorvastatin calcium in an organic solvent with/without a hydrophilic additive to prepare a drug solution; b) introducing the drug solution and carbon dioxide into a reactor, which maintains carbon dioxide at supercritical conditions, to produce atorvastatin calcium particles; and c) introducing carbon dioxide into the reactor to wash the particles through removal of the remaining organic solvent. The amorphous atorvastatin calcium prepared according to the method of the present invention has a particle size of nanometer order, large surface area and high solubility shows improved bioavailability, and thus can be formulated as various preparations for oral administration. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011088806-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011154755-A1 |
| priorityDate |
2007-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |