http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009117651-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5df2fb7f2ba738fe91a4187b7094720 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51b32eebeda618fafa25c6216286e803 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08 |
| filingDate | 2006-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c3175b126668c810fa705e85f58b9f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fade7a037c877766239f5c2ecc7dcc5d |
| publicationDate | 2009-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009117651-A1 |
| titleOfInvention | Nucleoside compounds and methods of use thereof |
| abstract | The present invention provides methods of utilizing a nucleoside derivative having the chemical formula of Formula (I) to downregulate expression of an anti-apoptotic protein such as survivin in a cell, induce apoptosis in a cell, inhibit angiogenesis in a cell, inhibit binding of p53 to DNA in a cell, inhibit phosphorylation of Akt in a cell and inhibit HIV transcription in a cell, by administering to the cell or tissue an amount of a compound of Formula (I) sufficient to achieve the desired activity. Formula (I): wherein the substituents R a , R b , R c , R d , R e , R f , R g , R h , R i and R k are as defined in the specification. A particularly preferred nucleoside derivative is ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carboxamide). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012060482-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9062088-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9403863-B2 |
| priorityDate | 2005-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 315.