http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009110636-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c72d118f5664072de841f9c5c34b9d99 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2007-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0692fbe34e78fc95dc1333858c425325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77ccfe8de0c414dd55ddf5429bc81ace http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef3582636d3276ba39105a878d0df13e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67c9f5a68df97f19e38574adab5a8486 |
| publicationDate | 2009-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009110636-A1 |
| titleOfInvention | Fluorinated dihydrotetrabenazine ether imaging agents and probes |
| abstract | The present invention provides novel fluorinated ether compounds having structure I n n n n n n n n n n wherein R 1 is a C 2 -C 10 fluorinated aliphatic radical; R 2 is a C 1 -C 10 aliphatic radical, or a C 3 -C 10 cycloaliphatic radical; R 3 is hydrogen or a C 1 -C 10 aliphatic radical; and R 4 is hydrogen or a C 1 -C 10 aliphatic radical. The fluorinated ether compounds are provided in both racemic and enantiomerically enriched forms and may comprise either or both of fluorine-18 and fluorine 19. The fluorinated ether compounds are shown to possess high affinity for VMAT-2, a biomarker implicated in human diabetes. The fluorinated ether compounds comprising a fluorine-18 group are useful as PET imaging agents targeting the VMAT-2 biomarker. The non-radiolabeled fluorinated ether compounds are useful as probes for the discovery of PET imaging agents. |
| priorityDate | 2007-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 768.