| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52646810ac18e369c6dd1d94280a00f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da5b327531ab0cd00f660f34f9286d87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4fb8322088f100fb5a8ed30d107835e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a8c4e0d39a012ec51d425b168be5c2b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-414 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-148
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1875 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-32 |
| filingDate |
2008-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_396281a9612651281a581ea31a4cd8e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1994887988489a8d99d6bb2a41a9ba03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adf53ad5068f7ba5a97c7d6d2c1c791b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14303e37711fea2c32773c30243cb406 |
| publicationDate |
2009-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009087472-A1 |
| titleOfInvention |
Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery |
| abstract |
Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(α-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015141345-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9161782-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101986447-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017032853-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008015580-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010130959-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773138-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011178465-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2456365-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11578110-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10118943-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8361129-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8361123-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822375-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9636109-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11192923-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011011285-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9642658-B2 |
| priorityDate |
2007-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |