| abstract |
A compound of Formula (I): Formula (I) wherein: R 1 is selected from hydrogen and C 1-4 alkyl; R 2 is selected from: R 4 —C(R 5a R 5b )—, R 4 ═C(R 6 )— and R 7a C(R 7b )═C(R 6 )—; R 3 X— is selected from methyl, methoxymethyl and; R 4 is selected from (optionally substituted) C 1-4 alkyl, phenyl, C 3-6 cycloalkyl and heteroaryl; R 5a and R 5b are independently selected from hydrogen, fluoro and C 1-4 alkyl; R 6 is selected from hydrogen and C 1-4 alkyl; R 7a and R 7b are optionally substituted C 1-4 alkyl; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described. |