| abstract |
The present invention is directed to certain compounds useful as phosphodiesterase 10 (PDE10) inhibitors that have the formula n n n n n n n n n n where R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined herein, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like. |