| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_233cf86dccb4bb6aca0a472f9027db92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2379ec39d233d3c03c319dedb17d33d9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-06 |
| filingDate |
2008-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_844c63e04c7d1a5e4510b25457e50dbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a457c1b8ffd7cc64cbd8d0fa8a613c2 |
| publicationDate |
2009-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009062247-A1 |
| titleOfInvention |
METHODS FOR INHIBITING TGF-beta |
| abstract |
The present invention provides methods for inhibiting or blocking TGF-β activity in cells and/or tissues expressing TGF-β comprising, contacting cells and/or tissues expressing TGF-β with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-β. The present invention further provides a method for treating a condition associated with overactivity of TGF-β or negative regulation in normal physiology by TGF-β in a subject in need of treatment, comprising contacting cells and/or tissue overexpressing TGF-β in the subject with an amount of cholesterol or cholesterol derivative effective to inhibit activity of TGF-β thereby treating the condition. In a preferred embodiment, the cholesterol derivative is oxidized 7-DHC. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11382904-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730722-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8487006-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010075923-A1 |
| priorityDate |
2007-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |