| abstract |
An isolated protein fragment containing an epitope which is specific for E. histolytica and is commonly shared by all polymorphic strains of E. histolytica is provided, and which exhibits immunogenicity in the host, and comprises an amino acid sequence containing amino acid sequence 603-1088 of SEQ ID NO: 2, and in particular, consists of the amino acid sequence 603-1088. An isolated DNA coding for such fragment, a vector containing such DNA, a host cell, a vaccine for amebiasis containing such fragment having a low molecular weight which can be stably produced in the host cell or E. coli in a large amount and at a high production efficiency, a method for producing such vaccine, an antibody against such fragment, and a method for preventing or treating amebiasis by administering such fragment are also provided. |