http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009054421-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1cfe242f0f35430601ac180fd3792aed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81c150af8961fd5ae4f74c3565019f3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4643569e4a1e527275b6d9241f614ac |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 |
| filingDate | 2006-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0781835bccc09acdb9ce8e33402edb14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8070723f3f6982c4f2367e6a6f1ac573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3df162b93d6f5c4babe8bc951a263c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e4121d866b91669764e65ad024e9373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_105c961b35ba11fb562bf456830b0e8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b58b6cd04f1c10eb28123ee65df2b6f |
| publicationDate | 2009-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009054421-A1 |
| titleOfInvention | Pyrimidothiophene Compounds Having HSP90 Inhibitory Activity |
| abstract | Compounds of formula (I) are HSP90 inhibitors, of utility in the treatment of, for example, cancers: wherein R 1 is -(Alk 1 ) p -(Z)r(Alk 2 )-Q wherein AIk 1 and AIk 2 are optionally substituted divalent C 1 C 3 alkylene or C 2 -C 3 alkenylene radicals, p, r and s are independently 0 or 1, Z is —O—, —S—, —(C═O)—, —(C═S)—, —SO 2 —, —C(═O)O—, —C(═O)NR A , —C(═S)NRA-, —SO 2 NR A —NR A C(═O)—, —NR A SO 2 — or —NR A — wherein R A is hydrogen or C 1 -C 6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R 2 is optionally substituted aryl or heteroaryl; R 3 is hydrogen, an optional substituent, or an optionally substituted (C 1 -C- 6 )alkyl, aryl or heteroaryl radical; and R 4 is (i) a carboxylic ester, carboxamide or sulfonamide group, or (ii) a —CN group, or (iii) an optionally substituted C 1 -C 6 alkyl, aryl, heteroaryl, aryl(C 1 -C 6 alkyl)-, or heteroaryl(C 1 -C 6 alkyl)- group, or (iv) a group of formula —C(═O)R 5 wherein R 5 is hydroxyl, optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aryl(C 1 -C 6 alkyl)-, aryl(C 1 -C 6 alkoxy)-, heteroaryl(C 1 -C 6 alkyl)-, or heteroaryl(C 1 -C- 6 alkoxy)-, or (v) a group of formula —C(═O)NHR 6 wherein R 6 is primary, secondary, tertiary or cyclic amino, or hydroxyl, optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aryl(C 1 -C 6 alkyl)-, aryl(C 1 -C 6 alkoxy)-, heteroaryl(C 1 -C 6 alkyl)-, or heteroaryKC 1 -C 6 alkoxy)-. |
| priorityDate | 2005-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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