http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009043111-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3f3ddd5e7778ce84b052ea80f39e12f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 |
| filingDate | 2007-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06c8550a8d1549f66f06b076dcc8a603 |
| publicationDate | 2009-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009043111-A1 |
| titleOfInvention | Novel process for ropinirole preparation |
| abstract | A method for producing compounds of the formula: n n n n n n n n n n Wherein R2 is selected from the group consisting of amino, lower alkylamino, di-lower alkylamino, allylamino, diallylamino, N-lower alkyl-N-allylamino, benzylamino, dibenzylamino, phenethylamino, diphenethylamino, 4-hydroxyphenethylamino or di-(4-hydroxyphenethylamino);n ncomprising:n a) reacting nn n n n n n n n n n with Wittig Reagent to produce n n n n n n n n n n wherein R1 is alkoxyl;n f) hydrolyzing compound II under acidic conditions to produce nn n n n n n n n n n n n g) subjecting compound III to reduction and amination to produce the tertiary amine n n n n n n n n n n n n n n n n wherein R2 is as defined above; n h) reacting compound IV with n 4-chlorophenoxyacetonitrile to create nucleophilic substitution to produce the nitrile compound n n n n n n n n n n n n n n n n wherein R2 is as defined above; and n i) effecting reduction and hydrolysis in the same step with palladium/C and sodium hydroxide to produce n n n n n n n n n n n n n n n n n n wherein R2 is as defined above. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9597301-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9017723-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9827207-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9913812-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9205061-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113214054-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9119799-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011072704-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10918607-B2 |
| priorityDate | 2007-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 190.