| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-24143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-24043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70528
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-235
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-863 |
| filingDate |
2007-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421ad8517f35233d47fc01e3671ad597
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d879d9050b86a10321e2766a73a3ae5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f63e812464d14004277af5a8d01516c |
| publicationDate |
2009-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009041804-A1 |
| titleOfInvention |
Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| abstract |
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of Tell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4 + and CD8 + T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11304976-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112292137-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11717539-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11512289-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11318163-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10857181-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019173462-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730761-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021015894-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11596652-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11497767-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11000548-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019165097-A1 |
| priorityDate |
1998-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |