http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009030205-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_105c5f09552598a95ffb6ac0dda26da6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 |
| filingDate | 2008-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6c0fd7aede9be11625717c2544de8b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6d52858b6452d0cb2a67e6e4b0cd74d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3b0a9f7df964e64b964c1177d07d8a1 |
| publicationDate | 2009-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2009030205-A1 |
| titleOfInvention | Process for obtaining cetirizine dihydrochloride |
| abstract | Process for the synthesis of cetirizine dihydrochloride, whereinn (a) a solution of {2-[4-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]}ethanol in 1-7 volumes, referred to the weight of {2-[4-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]}ethanol, of an organic solvent having a boiling point higher than 90° C. and being chosen from the group consisting of aliphatic, cycloalifatic or aromatic solvents is provided, whereafter (b) per equivalent of {2-[4-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]}ethanol employed, 1-2 equivalents of a metal haloacetate or of haloacetic acid, as well as 3-7 equivalents of an alkaly metal hydroxyde are added to the solution as per (a), providing a reaction mixture, where 0.05-0.3 volumes, referred to the weight of {2-[4-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]}ethanol employed, of water and 0.1-1.2 volumes, referred to the weight of {2-[4-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]}ethanol employed, of a polar aprotic, water miscible solvent are added, keeping the internal temperature of the reaction mixture below 60° C., whereafter (c) the cetirizine base formed within the reaction mixture is converted into its dihydrochloride salt and isolated as such. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018296404-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103497166-A |
| priorityDate | 2007-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.