| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff17ba8b613fdf6eae34a072c617cc58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cec0fc2e79fb43ec15073d1e6ce6787
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d3e824c398fa5eaba4aabff899765de |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-747
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 |
| filingDate |
2005-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1e42626cd104a0650f66df5ac3b47bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd44b5b495d6f708d14ba7754d284963
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2a5c73a1847bde87ddc463252b73e9c |
| publicationDate |
2009-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009028839-A1 |
| titleOfInvention |
Compositions and methods for the prophylaxis and treatment of vaginal infections |
| abstract |
Applicants have discovered that a particular bacteriocin from the vaginal strain of Lactobacillus rhamnosus , lactocin ( 160 ), possesses a particularly advantageous activity against microorganisms associated with vaginal infections, and more specifically those associated with Bacterial Vaginosis (BV). Specifically, this compound is an effective and non-cytotoxic antibacterial agent that provides the basis for formulations MW for the improved prophylaxis and treatment of vaginal infections, and attendant reduction in the acquisition and proliferation of HIV. Applicants have isolated and purified the antimicrobial peptide lactocin ( 160 ) from a vaginal strain of L. rhamnosus . The peptide shows antibacterial activity in an agar-well bioassay against the major BV-associated bacteria, G. vaginalis and anaerobes ( P bivia and Peptostreptococcus spp.) and does not inhibit the growth of lactobacilli species which are endogenous to a healthy vaginal environment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016237951-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113564075-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11174288-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11166968-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102554124-B1 |
| priorityDate |
2004-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |