| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61467be3f4402cb4ff76868fb5493ea0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9531e1bdbb4f8fde858971e410c1b28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a6129477cd711c79947ec9ababe3c02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_312a1b27c2312c9cff56db89775b30df |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-625 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-465 |
| filingDate |
2004-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b71400931903530bc039994f01524dba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f87f0e2ab9f3fcae798cb8f6e7f2f86b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfabd5a77640b18896d93a9dfe1cbdfe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c28b4aa26f1fb0ffeb9dbaf7885c50c4 |
| publicationDate |
2009-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009023185-A1 |
| titleOfInvention |
Avidin Mutants |
| abstract |
Two circularly permuted avidin monomers are designed. The circularly permuted monomers (cpAvd5→4 and cpAvd6→5) are fused and the resulting fusion peptides (dcAvd) form a pseudo-tetrameric dual-chain avidin, which is biologically active in biotin binding and shows similar structural characteristics as wild-type avidin. The dcAvd makes the development of dual-affinity avidins possible by allowing the adjustment of the ligand binding properties in the half of the binding sites differently than in the rest of the sites. The present invention provides further a single-chain avidin (scAvd) where two dcAvd-molecules are fused together via a linker to form a single polypeptide with four binding sites for biotin. |
| priorityDate |
2003-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |