http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009018266-A1

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filingDate 2006-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d5caf06a26cefd10c41c0fb669d0114
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f83bdfb6702e78d6072711c14239ad96
publicationDate 2009-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2009018266-A1
titleOfInvention Preparation of hydrophilic nanoparticles by copolymerization of mono and divinyl monomers in micellar solution
abstract The present invention relates to the preparation of hydrophilic nanoparticles and in particular hydrophilic nanoparticles that are biocompatible. Free radical monovinyl-divinyl monomer copolymerization/cross-linking reactions of water-soluble, monovinyl N-vinyl-2-pyrrolidone (NVP) with a bi-unsaturated divinyl, comonomer (poly{ethylene glycol}dimethacrylate) (PEGDMA), has been found to yield hydrophilic nanoparticles (NPs). These nanoparticles are built from three-dimensional nanopolymer networks. In the polymers' synthesis the composition of the monomers, and the total monomer concentration were varied. The characteristics of copolymers were determined by nuclear magnetic resonance spectroscopy (NMR), Fourier transform infrared (FTIR) and elemental analysis. Particle size and morphology of nanoparticles were confirmed by dynamic light scattering (DLS), transmission electron microscope (TEM) and scanning electron microscope (SEM) methods. In the present invention hydrophilic polymers can be used in micellar polymerization to create hydrophilic nanoparticles.
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priorityDate 2005-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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