| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b4f16ad70ddfeb0b838c113aaae408a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate |
2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e281536d0b4fc5374dfb2d4e10ab0d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86f298c66882cff926861cd940ead4a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae913d1fe3e4f1d66f0e8401fe017726
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e80107e622dc5b02541d1931f76e81b |
| publicationDate |
2009-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009012292-A1 |
| titleOfInvention |
Novel process for acyclic phosphonate nucleotide analogs |
| abstract |
The present invention provides a novel process for the preparation of acyclic phosphonate nucleotide analogs using novel intermediates. Thus, for example, (R)-9-(2-phosphonomethoxypropyl)adenine is reacted with dimethylformamide dimethylacetal to give N 4 -dimethylaminomethyledino-9-(2-phosphonomethoxy ethyl) adenine, which is then reacted with chloromethyl-2-propyl carbonate in presence of triethylamine to give (R)—N 4 -Dimethylaminomethyledino-9-(2-phosphono methoxypropyl) adenine disoproxil, followed by deprotection with acetic acid to get tenofovir disoproxil. Tenofovir disoproxil is then treated with fumaric acid to give tenofovir disoproxil fumarate. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110483575-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104804042-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112292-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104804042-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8519126-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103374038-A |
| priorityDate |
2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |