| abstract |
The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): n n n n n n n n n n [wherein —X—Y-Z- represents —O—CR 3 ═N— (wherein R 3 represents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, R 1 represents —NR 10 R 11 (wherein R 10 and R 11 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, R 2 represents —NR 13 R 14 (wherein R 13 and R 14 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof. |