http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008318799-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26acde46369081547d4007d976afa0e8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4719 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-9406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04 |
| filingDate | 2006-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fb1e3927e29923a83eda1d71cabc834 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2057a2dc0850133f6a73bd73c4e25c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f045e89d00d95fb611c4d8b384c1deba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e25149fe7e84a554b987e787fe724e42 |
| publicationDate | 2008-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008318799-A1 |
| titleOfInvention | Method of Quantifying the G Protein-Coupled Receptor (Gpcr)/G Protein Coupling Using a Cell Membrane Array |
| abstract | The invention relates to a method for quantifying G protein-coupled receptor (GPCR)-G protein binding by means of using a cell membrane array, which comprises (i) putting an unlabeled candidate compound in contact with a cell membrane array in the presence of labeled GTP or of a labeled, non-hydrolyzable analog thereof, in conditions allowing the interaction between said compound and said GPCR present in said cell membranes, and between said labeled GTP or analog thereof and said G protein present in said membranes; (ii) washing; and (iii) quantifying the signal obtained due to the binding of the labeled GTP (or analog) to said G protein. It is applicable in the analysis of the interaction between compounds and cell membrane receptor proteins and of the intracellular signaling mechanisms triggering this interaction mechanism mediated by said compounds. |
| priorityDate | 2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.