| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b10703cd555cc064a9432eaba3799fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7971e09720dfcd885d83296d40ffe9d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-986
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
2008-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6d9a6b3a611d0ad3077699769670cb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d568f42231f061272b65faecd515e09 |
| publicationDate |
2008-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008305496-A1 |
| titleOfInvention |
Method for identifying a compound that modulates SIR2 protein activity |
| abstract |
The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012088268-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103403553-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9249183-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012088268-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103403553-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105713957-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10072282-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105713957-B |
| priorityDate |
2007-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |