| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7bee24c10d58e60f4abd6a5ea5b0091 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3231 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2008-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f36487f0d689aa52a056e5d102066d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cf8f374e8dd93bd64310e79018e797d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b17beef8555220e12dc5afa6fc6343f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b93d7b682d4631c30ca17721ffe296fb |
| publicationDate |
2008-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008299659-A1 |
| titleOfInvention |
Nucleic acid compounds for inhibiting apob gene expression and uses thereof |
| abstract |
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing ApoB gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to an ApoB mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine, a nucleoside replaced with a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of an ApoB gene in a cell or in a subject to treat an ApoB-related disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11198869-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9273314-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10125366-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9637743-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8772262-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11685920-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739328-B2 |
| priorityDate |
2007-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |