abstract |
Disclosed are benztropinamine analogs having the formula I (I) in which E is NR 1 , S, or CH 2 ; B is NR 4 , O, or CH 2 ; m=1 to 5; n=1 to 3; Ar is a C 5 -C 20 monocyclic aryl group or a C 10 -C 20 bicyclic aryl group or a heteroaryl group having 2 to 6 carbon atoms and one or more heteroatoms selected from the group consisting of N, O, S, and any combination thereof; and bond “a” can be of α, β, or α/β configuration, wherein R 1 to R 5 are as described in the specification; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions and use thereof, e.g., in treating mental disorders. |