http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008267869-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0489 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F13-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F3-00 |
| filingDate | 2008-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d992241c814c9f122430ae3f117bd768 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dfd2b3ca979ce3411045301194a867d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_705c00cefe431b240db14c9cae497007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e171b10979305934388b2d914415395 |
| publicationDate | 2008-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008267869-A1 |
| titleOfInvention | Radioactive transition metal-imido hetero-diphosphine complexes, their preparation and radiopharmaceutical compositions thereof |
| abstract | The present invention provides radioactive metal heterocomplexes of formula (I): [(Me=N—R)L 1 L 2 ]+Z − (I), wherein Me, R, L 1 L 2 and Z − have the meanings indicated in the description. The complexes include a trivalent radioactive metal-imido group, typically a technetium- or rhenium-imido group, strongly stabilized by the presence of an ancillary tridentate hetero-diphosphine ligand L 1 , which allows the formation of substitution-inert [(Me=N—R)L 1 ] moieties. Such moieties are fixed in an intermediate [(Me=N—R)Y 2 L 1 )] + compound which contains two labile, cispositioned, Y ligands, where Y is preferably an halide group. The latter are easily replaced by a bidentate ligand L 2 to give the final [(Me=N—R)L 1 L 2 ] + Z − heterocomplexes. The complexes of the invention are useful for the preparation of radiopharmaceuticals: in fact, a bioactive fragment which confers biological target-seeking properties can be introduced either on the L 2 framework or the imido R group. |
| priorityDate | 2002-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.