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filingDate 2007-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bee3cea46ad8e280eb36aca19ad5ed5
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publicationDate 2008-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2008254032-A1
titleOfInvention Antibodies to M-CSF
abstract The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention.
priorityDate 2003-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0A3Q2TVI4
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http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID451512
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419556509
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP00722
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID4914
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID348
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID41457
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1G9Z4
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID57006608
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5789
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID36462
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395766
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ03WL0
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http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID4922
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP22303
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http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID12242
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP21836
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID453
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3851247
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8GGN3
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Total number of triples: 1083.