| abstract |
The present invention provides a highly durable packing material for liquid chromatography that is excellent in acidic resistance and alkalic resistance. Such a packing material for liquid chromatography can be obtained by chemically modifying silica gel with a bifunctional silane compound represented by the general formula [I], and carrying out an endcapping reaction of the resulting chemically modified silica gel using bifunctional cyclic silazane represented by the general formula [II]. In the formula [I], X 1 and X 2 , the same or different, represent a hydrogen atom, a halogen atom or an alkoxy group having 1 to 4 carbon atoms; and R 1 represents an alkyl group or an aryl group, which can have substituent(s). In the formula [II], R 2 and R 3 , the same or different, represent an alkyl group having 1 to 4 carbon atoms; and n represents a value indicating unit number that forms the ring, which is an integer of 2 to 10. |