| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7498a755446e3a1e93a1f100dd7302e8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-91558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2250-0068 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-148
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-915 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-06 |
| filingDate |
2007-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45ec2cf865efd4dbc86d2201056ec66b |
| publicationDate |
2008-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008243241-A1 |
| titleOfInvention |
Short term sustained drug-delivery system for implantable medical devices and method of making the same |
| abstract |
A short-term sustained drug eluting coating for implantable medical devices is disclosed. The coating comprises a biocompatible matrix and at least one pharmacologically or biologically active agent and releases substantially one of all of its payloads within four to six weeks post-implantation. When a combination of pharmacological agents are incorporated in the disclosed sustained drug eluting matrix of a drug/device combination, at least one agent is preferred to substantially release in a short duration. Medical devices benefiting from such a desired sustained drug eluting coating include drug eluting cardiovascular, peripheral, and neurovascular stents, abdominal aortic aneurysm (AAA) prosthesis, anastomosis shunt, arterial/venous (AV) shunts etc. One embodiment of the invention is a sustained release coating or depot on or in a stent that releases substantially all of it payload for ischemic myocardial injury after a heart attack. The coating may be formed from biocompatible stable and absorbable polymers of natural and synthetic origins. Useful pharmacological agents for inhibiting vascular neointimal growth post-angioplasty that leads to restenosis include macrolide polyenes such as a rapamycin and all its derivatives and analogs; paclitaxel and all derivatives and analogs. Useful agents for other vascular conditions such as vulnerable plaques may comprise anti-inflammatory, anti-proliferative agents, and matrix metalloprotease (MMP) inhibitors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018272042-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009155337-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9005696-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010304007-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010278894-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010280600-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011029070-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8858983-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010203100-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010198278-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109730819-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010161039-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8911427-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013138212-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2023190499-A1 |
| priorityDate |
2007-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |