| abstract |
Compounds of formula (I), combinations and uses thereof for disease therapy, n n n n n n n n n n or a pharmaceutically acceptable salt or solvate thereof, including all tautomers, stereoisomers and polymorphs thereof wherein:n nR 1 represents C 2-8 alkyl; C 2-8 alkenyl; —(C 1-6 alkyl)-aryl; —(C 1-6 alkyl)-heteroaryl; —(C 1-6 alkyl)-carbocyclyl; —(C 1-6 alkyl)-heterocyclyl; -aryl; -heteroaryl; -carbocyclyl or -heterocyclyl;n nwherein said aryl or heteroaryl groups may be optionally substituted by one or more substituents selected from, C 1-4 alkyl, C 1-4 -fluoroalkyl, C 1-4 alkoxy, C 1-4 -fluoroalkoxy, hydroxy,n n—SO 2 (C 1-4 alkyl), —SO 2 N(C 1-4 alkyl)(C 1-4 alkyl), —SOC 1-4 alkyl, —SOC 3-6 cycloalkyl —C(O)O(C 1-4 alkyl), benzyloxy and phenyl;n nand wherein said carbocyclyl and heterocyclyl groups may be optionally substituted by one or more substituents selected from —C 1-4 alkyl, —C 1-4 alkoxy, hydroxyl, halogen and oxo;n nR 2 represents H; C 1-4 alkyl or halogen;n nR 3 represents H; C 1-4 alkyl or halogen; andn nR 4 represents H; C 1-4 alkyl or halogen. |