| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33b011e77b33662b8bf1f2ff2de7b661 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-757 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
| filingDate |
2006-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bff15c1003bd63b0cf805ce383d65c8 |
| publicationDate |
2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008227722-A1 |
| titleOfInvention |
Targeted Drug Delivery of Pain and Addiction Therapies Using Opioid Receptor-Mediated Internalization |
| abstract |
Drug delivery is targeted to new opioid receptors using receptor-mediated internalization. Dermorphin was successfully conjugated to DSPE-PEG3400 without affecting the affinity to its receptor. The synthesized conjugate was inserted into preformed sterically stabilized liposomes to obtain dermorphin-grafted SSL. DSPE-PEG34Qo-dermorphin and dermorphin-SSL retained their affinity and selectivity for MOR. Moreover, dermorphin-SSL and encapsulated probes were taken up by CHO-hMOR cells, but not by naive CHO cells or very closely related CHO-hDOR cells. Dermorphin-SSL can be used to deliver drugs to the intracellular component of intended cells with high fidelity. Therefore, dermorphin-SSL is useful to carry pharmaceutical agents to achieve region-specific delivery of analgesics and/or to attenuate side effects associated with opioids. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015307550-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10577405-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9856306-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015031630-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022045398-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10005817-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10010617-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11065304-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11541028-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10420844-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10471127-B2 |
| priorityDate |
2005-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |