| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba596f6a55175fe225331a7b8a5b5db3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e34a5ce589132b213c906bccd11fe452
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75f2a579a509cf6ef981af4ec0a868c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb3b874314f72fd14b113d668789923c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate |
2008-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_234cdf79fe03e997e61cf6123489b51e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_135ab23948e2301665226cdd6a164c66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62be3b252f86aa8a1c69fd7cedbd307f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_991866f1533038559e83a414c114688f |
| publicationDate |
2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008227708-A1 |
| titleOfInvention |
Methods Of Attenuating Prostate Tumor Growth By Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) |
| abstract |
Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) inhibits cell growth and promotes apoptosis by sequestering free Insulin-like Growth Factor (IGF), and also demonstrates IGF-independent, pro-apoptotic, anti-proliferative effects on prostate cancer cells. Prostate tumor size was significantly attenuated in transgenic mice over-expressing IGFBP-3 compared with wild-type mice. In addition, a marked reduction in late-stage tumor growth was apparent in transgenic mice over expressing mutant-IGFBP-3 indicating that the IGF-independent effects of IGFBP-3 are related to inhibiting tumor progression. |
| priorityDate |
2005-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |