| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cac333b75c636c08618815734ae4b833
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fb40ecf0b2fbf644c25eb17bf756899
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1413445ab1452a5d425064cf1785a2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c025cc0cce6e61f5dbfe09f915bda26 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56988 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 |
| filingDate |
2008-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e813fb19051902b8ffd191e13150da60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0620a4824bdaa93a304e5e528937293f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6b59428e74be5290699120656ef0af0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89320977bd7dd40ab96f26e52a92757d |
| publicationDate |
2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008227084-A1 |
| titleOfInvention |
Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients |
| abstract |
A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus can be shifted back to CCR5-mediated entry after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CXCR4 specific strains. The diagnostic methods can be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. |
| priorityDate |
2000-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |