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filingDate 2006-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a0cc73d6e29a23d856506704ca84740
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publicationDate 2008-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2008215252-A1
titleOfInvention Method of Determining Base Sequence of Nucleic Acid and Apparatus Therefor
abstract In a preferred embodiment, an exploring needle of a probe 2 is located at the position of each base of a nucleic acid 6 , and a tunneling current value is set to a given value measure. When a bias voltage applied to a substrate is changed step by step from −6 V to 4 V, according to the height of an observed image of each base, the electronic state distribution pattern of each base is obtained. The thus obtained electronic state distribution pattern of each base in the nucleic acid as a measurement object is checked against those in a database to find a base species having the highest degree of similarity to each base by pattern matching to identify each base species to determine the base sequence of the nucleic acid.
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