| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41a639aa11b9b2f8063a3e6b8b22b557 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-644
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21022 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36 |
| filingDate |
2008-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a77d50636b1d364378e56ba424015a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a550c8b57a0f84f7bf6a546b9f8b3a60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee289da9890a6531704e5a8d5ab107c9 |
| publicationDate |
2008-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008214461-A1 |
| titleOfInvention |
FVIII-Independent FIX-Mutant Proteins for Hemophilia A Treatment |
| abstract |
The present invention relates to recombinant blood coagulation factor IX (rFIX) mutants having factor VIII (FVIII) independent factor X (FX) activation potential. Five full length FIX proteins with combinations of mutations of amino acids important for functional activity of FIX and FIX wild type were cloned and expressed in HEK 293 cells. The proteins were tested by an activated partial thromboplastin time (aPTT) assay in FVIII-depleted plasma as well as in FVIII-inhibited patient plasma. In FVIII-depleted plasma functional activity of the FIX mutants was calculated as increased FVIII equivalent activity. The mutant proteins had increased FVIII equivalent activity. In FVIII-inhibited patient plasma the FEIBA equivalent activity was calculated for analysis of FVIII independent FX activation potential. The proteins had also increased FEIBA equivalent activity. Furthermore, the pre-activated FIX proteins had an increased activity in FIX-depleted plasma containing FVIII inhibitors. Therefore these FIX mutants are alternatives as bypassing agents for treatment of FVIII inhibitor patients. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10125357-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865154-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11491212-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021154414-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8778870-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9328339-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10883097-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011217284-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10982203-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012061654-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3663399-A1 |
| priorityDate |
2007-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |