http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008207652-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29e6e822cbfd4f0d07c825b775c1d9dc |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
filingDate | 2008-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8bcd6441bf4d100d478ab8e1746c3b1 |
publicationDate | 2008-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2008207652-A1 |
titleOfInvention | Novel inhibitors of folic acid-dependent enzymes |
abstract | The invention relates to compounds of the formula I, or pharmaceutically acceptable salts thereof: n n n n n n n n n n n n wherein: n Z=O or S; n n=1-3; n R 3 ═—CO 2 R 8 , —C(O)SR 8 , —C(O)NHR 8 , —C(S)OR 8 , —C(S)SR 8 , —C(S)NHR 8 , —C(NH)SR 8 or —C(NH)NHR 8 ,n wherein R 8 is —H or alkyl; n n R 4 ═—H, —CH 2 R 5 or —CH 2 CH 2 R 5 ,n wherein R 5 independently has one of the meanings of R 3 ; n n B═—NR 2 —, —CH 2 NR 2 —, —CH 2 CH 2 NR 2 —, —CH 2 CHR 7 — or —CH 2 O—,n wherein R 2 is H or a C 1-3 alkyl, alkenyl or alkynyl group, andn R 7 is H or a C 1-3 alkyl or alkoxy group; n n n n n n n n n n n n n n n n wherein R 1 ═—NH 2 or —OH, and C and D are each, independently, a 5- or 6-membered, substituted or unsubstituted, aromatic or non-aromatic ring which may also contain one or more heteroatoms, and C is connected to group B in any available position. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112126-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8530653-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010249141-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8518954-B2 |
priorityDate | 2005-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1585.