http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008207503-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aba4fb0c9c3c22dccd1e1dc1490c7628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_206748b18ec5fcb934f3ffbcdc17bb42 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 |
| filingDate | 2005-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26fdc7ba571030e16ba036638db9545c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad3507ad1bcf30f93a53e41af70b7124 |
| publicationDate | 2008-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008207503-A1 |
| titleOfInvention | Composition and Treatment Methods for Coronary Artery Disease |
| abstract | The present disclosure demonstrates that cholesterol-free discoidal reconstituted HDL (R-HDL), phosphatidyl-choline (PC) and PC liposomes effectively released cholesterol from ICP. Native HDL and its apolipoproteins were not able to release cholesterol from ICP. The release of ICP cholesterol by R-HDL was dose-dependent and accompanied by the transfer of >8× more PC in the reverse direction (i.e., from R-HDL to ICP), resulting in a marked enrichment of ICP with PC. The enrichment of ICP with PC resulted in the dissolution of cholesterol crystals on ICP and allowed the removal of ICP cholesterol by apo HDL and plasma. The present disclosure provides a method of treatment for removal of cholesterol from ICP in vivo and compositions for use in such method of treatment. Such methods may be used in the treatment and/or prevention of atherosclerosis, coronary artery disease, and related disease states and conditions. |
| priorityDate | 2005-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 168.